Functional Cardiorespiratory Toxicity Screening of Candidate Antiparasitic Drugs and Antidotes for Chemical Poisons. Study of the Effects of Drugs Upon the Cardiovascular and Respiratory Systems
Abstract
During this past year we have: 1. Completed study of the Cardiovascular and Pulmonary Effects of Pyridostigmine Bromide in the Dog: Correlation with blood cholinesterase Inhibition. A copy of this report is attached (Section I). 2. Written a protocol to study the Effects of Choloroquine and Mefloquine Individually and in Combination Upon Automaticity, Rhythmicity, and Dynamics of the Heart. A copy of this protocol is attached (Section II). A range of doses of pyridostigmine were infused intravenously into anesthetized beagle dogs to determine the minimal effective and the maximum tolerated doses upon cardiovascular and pulmonary function and blood cholinesterase (Che) activity. The 0.5 mg/kg dose of pyridostigmine produced a slight (10%) fall in tidal volume and airway compliance, a 200% increase in airways resistance, but no change in respiratory rate or minute volume. This dose also produced a 10% fall in heart rate, a small increase in cardiac output (8%), stroke volume (20%) and pulmonary artery (15%) and wedge pressure (2mmHg), and a 35% fall in blood Che activity.Keywords: Cardiopulmonary, Pyridostigmine bromide , Compliance, Resistance, Cholinesterase, Chloroquine, Mefloguine, Automaticity, Rhythmicity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1988
- Accession Number
- ADA201912
Entities
People
- Clinton B. Nash
- Robert W. Caldwell
Organizations
- Medical College of Georgia