Drug Development against Viral Diseases

Abstract

Seventy-three compounds were tested for toxicity and/or antiviral activity against Congo-Crimean hemorrhagic fever (CCHF) virus in infant mice. Most compounds were tested using a single dose drug administered 45 minutes before virus. Nine drugs were also tested after multiple doses of drug. Date were analyzed for protective effect (PE) and geometric mean time to death (VR). PE and VR correlated so that the VR will serve in the future as the sole measure of drug efficacy. Variation in teh geometric mean time to death for mock-treated control (VC) and positive drug control animals (VR+) was determined. Standard errors for VC were 0.66 days for single dose experiments and 0.73 days for multiple dose experiments. Variation about the values for the positive control was lower with SE of 0.13 and 0.14 days for single and multiple dose experiments, respectively. Keywords: Antivirus agents; Anti-viral drug; Lymphocytic choriomeningitis virus; Crimean-congo hemorrhagic fever virus; Yellow fever virus.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1987
Accession Number
ADA201949

Entities

People

  • Gregory H. Tignor

Organizations

  • Yale University

Tags

DTIC Thesaurus Topics

  • Animals
  • Antigens
  • Brain
  • Cells
  • Central Nervous System
  • Data Analysis
  • Diseases And Disorders
  • Endothelial Cells
  • Epithelial Cells
  • Kidneys
  • Nervous System
  • Rodents
  • Toxicity
  • Viral Hemorrhagic Fevers
  • Virtual Reality
  • Virus Diseases
  • Yellow Fever

Fields of Study

  • Biology
  • Medicine

Readers

  • Theoretical Analysis.
  • Virology (or Medical Virology).