Molecular Characteristics of Membrane Glutamate Receptor-Ionophore Interaction
Abstract
The overall objective of these investigations was to develop the procedures for precise quantitation and molecular definition of glutamate- sensitive binding sites and ion channels in the mammalian brain, and to apply this technology to neurons maintained in culture. These investigations were based on the refinement of technology developed in our laboratories for the isolation of a glutamate binding protein (GBP) from mammalian brain synaptic membranes. This protein represents a component of the macromolecular complex of glutamate-activated membrane receptors. Glutamate receptors, Ion channels, Synaptic membranes, Antibodies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 19, 1988
- Accession Number
- ADA201954
Entities
People
- Elias K. Michaelis
Organizations
- University of Kansas