Acute Dermal Toxicity of Diethyleneglycol Dinitrate in Rabbits
Abstract
The acute dermal toxicity of diethyleneglycol dinitrate, DEGDN, was evaluated in male and female New Zealand White rabbits. Neat DEGDN was applied topically to the clipped dorsal skin surface under a semi-occlusive wrap for 24 hours. A limit dose of 2 g/kg did not produce deaths or clinical (systemic or dermal) signs, during the two-week observation period, that could be directly attributed to administration of the DEGDN. One intriguing observation was the occurrence of curly new hair growth on 6 of the 10 rabbits in the area where DEGDN had been applied. Acute dermal toxicity, Diethyleneglycol dinitrate, DEGDN, Rabbit, Propellant, Munition.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1988
- Accession Number
- ADA201956
Entities
People
- Don W. Korte Jr.
- Larry D. Brown
Organizations
- Letterman Army Hospital