Acute Subcutaneous Toxicity of Physostigmine Salicylate in Sprague-Dawley Rats
Abstract
The acute subcutaneous toxicity of physostigmine salicylate was determined in male and female Sprague-Dawley rats using the single-dose method. The median lethal dose was 1.78 mg/kg plus or minus 0.07 mg/kg for male and 1.54 mg/kg plus or minus 0.08 mg/kg for female rats. Clinical signs observed were primarily related to changes in behavior, such as tremors, hypertonia, irritability, somnolence, inactivity, and ataxia. Other noted clinical signs included lacrimation, salivation, and diarrhea. The duration of the clinical signs was acute. Most animals were exhibiting signs by 1 hour after dosing and had either died or returned to normal by 4 hours after dosing. According to the classification scheme of Hodge and Sterner, these results place physostigmine salicylate in the highly toxic class. Keywords: Acute subcutaneous toxicity, Physostigmine salicylate.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1988
- Accession Number
- ADA201957
Entities
People
- Denzil F. Frost
- Don W. Korte Jr.
Organizations
- Letterman Army Hospital