Dermal Sensitization Potential of Niclosamide in Guinea Pigs

Abstract

Niclosamide, the active ingredient in a schistosome topical antipenetrant lotions, was tested for its potential to produce dermal sensitization. The guinea pig maximization test was used to evaluate dermal sensitization potential. Grade III (moderate) dermal sensitization to the niclosamide was obtained in this study. These results suggest that there is probable risk that the active ingredient in the schistosome topical antipenetrant lotion will induce contact sensitivity in humans. Dermal sensitization, Schistosome topical antipenetrant lotion, Guinea pig maximization test, Niclosamide, Guinea pigs.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1988
Accession Number
ADA201958

Entities

People

  • C. D. Smith
  • Conrad R. Wheeler
  • Denzil F. Frost
  • Don W. Korte Jr.
  • Gary M. Zaucha
  • Robert E. Harris

Organizations

  • Letterman Army Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Bandages
  • Biological Sciences
  • Biomedical Research
  • Body Weight
  • Health Services
  • Infectious Diseases
  • Lymphatic Diseases
  • Lymphatic System
  • Medical Personnel
  • Military Personnel
  • Military Research
  • Physicians
  • Propylene Glycol
  • Quality Control
  • Tissues
  • Toxicology

Fields of Study

  • Biology

Readers

  • Marine Ecological Systems Migration
  • Neurotoxicology
  • Rocket Propulsion.