Dermal Sensitization Potential of Diethyleneglycol Dinitrate (DEGDN) in Guinea Pigs

Abstract

The Department of Defense is considering the use of either diethyleneglycol dinitrate (DEGDN), triethyleneglycol dinitrate (TEGDN), or trimethylolethane trinitrate (TMETN) as a replacement for nitroglycerin in new propellant formulations. However, considerable gaps in the toxicology data of the compounds were identified during a review of their health effects (1) conducted for the US Army Biomedical Research and Development Laboratory (USABRDL). Consequently, USABRDL has tasked the Division of Toxicology, Letterman Army Institute of Research (LAIR), to conduct an initial health effects evaluation of the proposed replacement nitrate esters. Keywords: Dermal sensitization, Diethyleneglycol dinitrate, DEGDN, Buehler test, Guinea pigs.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1988
Accession Number
ADA201959

Entities

People

  • Don W. Korte Jr.
  • Gerald F. Hiatt
  • John R. Ryabik

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Animals
  • Biomedical Research
  • Department Of Defense
  • Health
  • Health Services
  • Immune System
  • Laboratory Animals
  • Materials
  • Medical Personnel
  • Propellants
  • Rodents
  • Spectra
  • Toxicity
  • Triple Base Propellants
  • United States

Readers

  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology
  • Biotechnology - Bioremediation