Primary Eye Irritation Potential of Diethyleneglycol Dinitrate (DEGDN) in Rabbits

Abstract

The potential for diethyleneglycol dinitrate (DEGDN) to produce primary eye irritation was evaluated in six male New Zealand White rabbits by using a modified Draize method. DEGDN produced no response indicative of a potential to cause irritation upon direct contact with the eye. Slight iridial vasodilation (one of six rabbits) and slight conjunctival vasodilation and swelling, indicative of mild inflammation, (three of six rabbits) were the most serious responses observed. DEGDN was classified as a non-irritant under conditions of this study. Diethyleneglycol dinitrate, DEGDN, Ocular irritation, Mammalian toxicology, Rabbits.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1988
Accession Number
ADA201961

Entities

People

  • Don W. Korte Jr.
  • Gerald F. Hiatt

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Animal Structures
  • Biomedical Research
  • Body Weight
  • California
  • Classification
  • Cornea
  • Department Of Defense
  • Detection
  • Explosives
  • Eye
  • Health Services
  • Materials
  • Propellants
  • Rodents
  • Toxicity
  • United States

Readers

  • Toxicology/Environmental Toxicology