Resuscitation of Conscious Pigs Following Hemorrhage: Comparative Efficacy of Small-Volume Resuscitation with Normal Saline, 7.5% NaC1, 6% Dextran 70, and 7.5% NaC1 in 6% Dextran 70
Abstract
The effect of small-volume resuscitation (4 ml/kg) with hypertonic saline/dextran (HSD) (7.5% NaCL in 6% Dextran, n=6), hypertonic saline (HS) (n=8), dextran (n=6), or normal saline (0.9% sodium chloride, n=8) was evaluated in chronically instrumented, splenectomized conscious swine bled 37.5 ml/kg over 60 min. Hemorrhage resulted in a reduction in cardiac index, stroke volume index, and mean arterial pressure. Survival with HSD (66%) was better than the other three treatments. The survival rate due to HS (25%) was greater than that due to normal saline (0%) but was not different than that of dextran (17%). HSD and HS expanded plasma volume by 33 and 29%, respectively. Administration of HSD or HS acutely improved cardiac index and stroke volume, and decreased heart rate. The increases in cardiac index and stroke volume were greater following resuscitation with HSD and the improvement persisted over 3 h. Mean arterial pressure was acutely increased after administration of HSD but returned to post-hemorrhage values within 30 min. Plasma sodium cation concentration and osmolality were increased to a similar extent with HSD and HS, while plasma potassium cation levels were initially decreased, returning to control levels within 60 min. HSD appears to be a superior small-volume resuscitation solution compared to the other treatments with no detrimental effects noted in the present study of conscious swine.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1988
- Accession Number
- ADA201962
Entities
People
- C. A. Bossone
- Charles E.W. Wade
- J. A. Loveday
- J. P. Hannon
- M. M. Hunt
- R. Coppes
- V. L. Gildengorin
Organizations
- Letterman Army Hospital