Recognition of Typhus Group Rickettsia-Infected Targets by Human Lymphokine-Activated Killer Cells

Abstract

Lymphokine-activated killer cells caused significant lysis of target cells infected with typhus group rickettsiae (TGR) but not cells infected with Rickettsia tsutsugamushi. Monoclonal and polyclonal antibodies against TGR or TGR-infected cells failed to bind specifically to infected targets, as determined by flow cytometry or by immunoprecipitation of radiolabeled cell surface proteins. Major unaltered antigenic determinants of TGR therefore cannot be detected on the surface of infected targets. Keywords: Bioassay; Binding sites.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1988
Accession Number
ADA202172

Entities

People

  • Gregory A. Dasch
  • Mitchell Carl
  • Wei-mei Ching

Organizations

  • Naval Medical Research Center

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Antigens
  • Biomedical Research
  • Blood
  • Cells
  • Chlamydia
  • Immune Serums
  • Immunity
  • Infection
  • Infectious Diseases
  • Lagomorphs
  • Lymphocytes
  • Microbiology
  • Proteins
  • Recognition
  • Rickettsial Diseases
  • T Lymphocytes

Fields of Study

  • Biology

Readers

  • Immunology
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.