Sulfur Mustard (SM) Lesions in Organ-Cultured Human Skin: Markers of Injury and Inflammatory Mediators

Abstract

In this research program, we are (a) developing an in-vitro human skin model with which to assess the amount of injury produced by topically applied sulfur mustard (SM), and (b) identifying the early mediators of the inflammatory response produced by SM in human skin. Keywords: Sulfur mustard; Human skin lesions; Histology & histochemistry; Inflammatory mediators; Organ culture; Paranuclear vacuolization test for epidermal injury; C14 Leucine incorporation; Chemotaxis of granulocytes and macrophages; Lysozyme (lactic dehydrogenase); Trypsin-like and chymotrypsin-like enzymes; Angiotensin- converting enzyme; Plasminogen activator.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1988
Accession Number
ADA202373

Entities

People

  • Arthur M. Dannenberg Jr.

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Biomedical And Dental Materials
  • Blood
  • Blood Proteins
  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Chlorides
  • Death
  • Dermatologic Agents
  • Dilution
  • Environmental Health
  • Macrophages
  • Medical Personnel
  • Skin Diseases
  • Surgery
  • Vascular Diseases

Fields of Study

  • Biology

Readers

  • Geochemistry
  • Immunology and Pathology
  • Molecular and Cellular Biochemistry