Gating Kinetics and Ion Transfer in Channels of Nerve Membrane
Abstract
Whether the kinetics and thermodynamics of electric-field initiated alteration of nerve membrane to the conduction of specific ions through ion channels (gating) can be validly described by linear, equilibrium models will be determined by examining the time reversal properties of ion channel current fluctuations. The kinetics of gated channels derived from analysis of stochastic current fluctuations and those derived from linear macroscopic determinations (membrane complex admittance determinations) will be compared to ascertain whether the assumed relationship exists. Keywords: Nerve conduction kinetics, Membrane admittance, Thermodynamics of gating, Nerve transmission, Axons.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 09, 1988
- Accession Number
- ADA202509
Entities
People
- Harvey M. Fishman
Organizations
- University of Texas Medical Branch