Anti-Cyanide Drugs

Abstract

The extent of cyanide uptake by various molecules at pH 7.4 was monitored with a cyanide specific electrode. Low molecular weight aliphatic aldehydes scavenged cyanide best, followed by aromatic aldehydes with electron withdrawing functions. Palladium(II) complexes rapidly bound four moles of cyanide, gold(III) species bound three, while platinum(II, IV) and trivalent rhodium and ruthenium complexes were less reactive. A ruthenium porphyrin complexed two cyanides in both the +2 and +3 oxidation states. A nickel(II) schiff-base adduct took up four moles of cyanide through a dissociative process. Nickel(II) cyclams rapidly bound one cyanide, and three more at later times. Keywords: Metalloporphyrins, Cyanohydrins, Ketones, Metal complexes, Antidotes.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
May 01, 1988
Accession Number
ADA203298

Entities

People

  • Peter Hambright

Organizations

  • Howard University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Aldehydes
  • Biomedical Research
  • Chemical Synthesis
  • Chemistry
  • Classification
  • Coordination Complexes
  • Hydroxides
  • Imines
  • Kinetics
  • Metals
  • Molecular Weight
  • Organic Chemistry
  • Security

Fields of Study

  • Chemistry

Readers

  • Organic Chemistry
  • Toxicology/Environmental Toxicology

Technology Areas

  • Microelectronics