Cardiorespiratory Effect of Brevetoxin (PbTx-2) in Conscious, Tethered Rats

Abstract

The cardiorespiratory effects of various doses of brevetoxin (0 - 100 micrograms PbTx-2/kg) were studied in conscious, tethered rats. After surgical preparation and a 24 hr recovery, toxin or vehicle was infused into the tethered, awake rats for 1 hr. They were then monitored for 6 hr or until death. Toxin-infused rats had decreased core and peripheral temperatures and decreased respiratory rates; these values were all low in the 100 micrograms/kg group at the time of death. Blood gas values remained within normal limits, except terminally. Electrocardiographic (ECG) disturbances, noted in all groups given > or = 25 micrograms/kg, included heart block, premature ventricular contractions and idioventricular rhythms. It was concluded that brevetoxin causes changes in cardiac conduction and multiple changes in nervous system function.

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Document Details

Document Type
Technical Report
Publication Date
Nov 07, 1988
Accession Number
ADA203316

Entities

People

  • Charles B. Templeton
  • Mark A. Poli
  • Ross D. Leclaire

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Blood Gases
  • Body Temperature
  • Cardiac Arrhythmias
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Central Nervous System
  • Health Services
  • Membrane Potentials
  • Monitoring
  • Nervous System
  • Rodents
  • Veins

Fields of Study

  • Biology
  • Chemistry
  • Medicine

Readers

  • Cardiovascular Physiology
  • Toxicology/Environmental Toxicology