Acute Inhalation Toxicity of T-2 Mycotoxin in Mice and Guinea Pigs
Abstract
In this study a concentration-response was determined for rats and guinea pigs systematically exposed to an aerosol of T-2 toxin. The LC50 for a 10 min exposure to T-2 toxin aerosol was 0.020 mg T-2/liter air for rats and 0.21 mg T-2/liter air for guinea pigs. Data from total T-2 deposition in rats and guinea pigs exposed to their respective LC50 aerosol concentration gave an LD50 of 0.046 mg T-2/kg body weight for the rat and 0.50 mg T-2/kg body weight for the guinea pig. These data show that inhaled T-2 toxin is at least 10 times more toxic to the rat (0.046 mg T-2/kg body weight inhaled vs 1.0 mg T-2/kg body weight systemic) and twice as toxic to the guinea pig (0.5 mg T-2/kg body weight inhaled vs. 1-2 mg T-2 kg body weight systemic) than systemically administered T-2 toxin. Guinea pigs exposed to T-2 aerosols with varied times and aerosol concentration showed that when given the same received dose over a shorter interval of time, T-2 was more toxic, Histopathology of major organs in both the rat and guinea pig after respiratory exposure to T-2 toxin was similar to that after systemic administration of T-2 toxin. Histopathology of the respiratory tract after T-2 aerosol exposure was minimal and could not account for the increased toxicity of inhaled T-2 toxin. Keywords: Phytotoxins.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 23, 1988
- Accession Number
- ADA203373
Entities
People
- D. L. Bunner
- Donald A. Creasia
- J. D. Thurman
- R. W. Wannemacher
Organizations
- United States Army Medical Research Institute of Infectious Diseases