The Role of Cytomegalovirus as a Cofactor in the Development of ARC-AIDS
Abstract
The first phases of this project involved collection of sera, saliva and urine for storage and retrieval for antibody and virus isolation studies. Initial studies allowed development and modification of methodology and the identification of subjects in Groups 1,2, and 3. The second phase of the work is now well under way, i.e., to obtain data aimed at determining whether CMV may play a role as a triggering cofactor with HIV to initiate rapid progression of disease. Time is required for significant numbers of the 600 subjects to progress; it will be several years before a sufficiently large number will have progressed to be adequate for valid statistical analysis. This report describes some aspects of the study which we have been able to address recently, while we wait for disease progression in occur in sufficient numbers of subjects. Most of the information presented in previous quarterly reports is not repeated in this report. Data has been generated on patterns of herpes simplex virus antibody production, as well as the CMV studies. This is because herpes simplex virus (HSV), particularly type 2, may be involved significantly in the initial venereal infection by HIV (through and from herpetic ulcers) and both CMV and HSV are now known to trigger HIV out of a latent state in vitro.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1988
- Accession Number
- ADA203448
Entities
People
- Joah M. Ratner
- Kendall O. Smith
Organizations
- University of Texas Health Science Center at San Antonio