Cardiovascular Performance with E. coli Challenges in a Canine Model of Human Sepsis

Abstract

We investigated cardiovascular dysfunction by injecting lethal and nonlethal bacterial challenges into conscious dogs. E. coli bacteria of varying numbers were placed in a peritoneal clot. Cardiovascular function was studied with simultaneous radionuclide scans and thermodilution cardiac outputs. In surviving animals, the number of bacteria in the clot increased as the corresponding systolic cardiac function decreased (P= 0.01). Cardiac function was measured by left ventricular (LV) ejection fraction (EF) and LV function curves LV stroke work index (LVSWI) vs. end-diastolic volume index (EDVI) and peak systolic pressure vs end-systolic volume index. Reprints.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1988
Accession Number
ADA203467

Entities

People

  • Charles Natanson
  • Mitchell P. Fink
  • Richard I. Walker
  • Robert L. Danner
  • Thomas J. Macvittie

Organizations

  • Naval Medical Research Center

Tags

DTIC Thesaurus Topics

  • Abnormalities
  • Animals
  • Arteries
  • Bacteria
  • Base Lines
  • Birds
  • Blood
  • Blood Flow
  • Cardiovascular Physiological Processes
  • Dysfunction
  • Ejection
  • Heart Rate
  • Hemorrhagic Shock
  • Microorganisms
  • Security
  • Sepsis
  • Surgery

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology
  • Microbial Pathology