Ninety-Day Subchronic Oral Toxicity Study of Nitroguanidine in Mice
Abstract
The 90-day subchronic oral toxicity of nitroguanidine was evaluated in male and female ICR mice. The addition of nitroguanidine to the diet had no effect on food consumption or weight gains, but there was a significant dose- response increase in water consumption. Clinical signs attributable increase in water consumption. Clinical signs attributable to the test compound were not observed during the study. Blood samples taken at necropsy for hematological analysis exhibited no significant abnormalities that could be attributed to nitroguanidine dosing. Brain-to-body weight ratio in the high-dose males, organ weights and their respective ratios were not significantly affected by dosing. These findings indicate that nitroguanidine is nontoxic in mice when administered at doses as high as 1000 mg/kg/day for 90 days. The findings of increased water consumption suggest that nitroguanidine, which is excreted unchanged in the mouse's urine, may be acting as an osmotic diuretic. Keywords: Subchronic oral toxicity, Nitroguanidine, ICR mice, Triple base propellants.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1988
- Accession Number
- ADA203757
Entities
People
- Denzil F. Frost
- Earl W. Morgan
- Michael J. Pearce
- Suellen Ferraris
- Yvonne Letellier
Organizations
- Letterman Army Hospital