Small Volume Resuscitation of Hypovolemic Shock

Abstract

Studies were performed to evaluate the importance of the dextran component in hypertonic saline/dextran. Hemorrhaged awake sheep were resuscitated with 7.5% NaCl alone (HS) 7.5% NaCl /6% dextran and 7.5% NaCl/24% dextran. There was a dose related effect between the dextran infused and the improvement in blood pressure, cardiac output and volume expansion. These differential responses were apparent immediately post resuscitation and became larger during the first 2-3 40 ml injections were required to maintain cardiovascular function at baseline levels. Higher concentrations of salt (28% NaCl) with 24% dextran were shown to effectively resuscitate a 1.2 - 1.8 l blood loss in volumes as small as 40 ml. Keywords: RA II; Lab animals; Rats; Sheep; Hypertonic resuscitation; Peripheral vein injections; Blood loss; Therapy; Blood substitutes. (kt)

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1988
Accession Number
ADA203784

Entities

People

  • George C. Kramer

Tags

DTIC Thesaurus Topics

  • Arteries
  • Blood
  • Blood Volume
  • Cardiovascular Physiological Phenomena
  • Health Services
  • Hemorrhage
  • Hemorrhagic Shock
  • Laboratory Animals
  • Military Hospitals
  • Resuscitation
  • Security
  • Sodium Compounds
  • Therapy
  • Volume

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Trauma Surgery or Emergency Medicine.