Mutagenic Potential of Physostigmine Salicylate in the Ames Salmonella/ Mammalian Microsome Mutagenicity Test

Abstract

The mutagenic potential of physostigmine salicylate was assessed by using the Ames Salmonella/Mammalian Microsome Mutagenicity Test. Tester stains TA97, TA98, TA100, TA102, TA1535, TA1537, and TA1538 were exposed to doses ranging from 0.2 mg/plate to 0.00064 mg/plate. The test compound was not mutagenic under conditions of this test. Physostigmine salicylate, Mutagenicity, Genetic toxicology, Ames test.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1988
Accession Number
ADA203802

Entities

People

  • John W. Harbell
  • Suzanne E. Sebastian

Organizations

  • Letterman Army Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biological Sciences
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemistry
  • Classification
  • Liquid Chromatography
  • Materials
  • Mutagenicity Tests
  • Nerve Agents
  • Nervous System
  • Plastic Explosives
  • Salicylates
  • Security
  • Therapy
  • Toxicity
  • Toxicology

Readers

  • Microbial Pathology
  • Neurotoxicology
  • Surface Coatings Technology.

Technology Areas

  • Biotechnology