The Effects of Acute Alterations in Hemodynamics Oxygen Availability and Acid-Base Balance on the Permeability of the Gastric Mucosa
Abstract
Using a previously described model for acute gastric mucosal ulcerogensis, studies indicate the following: (1) Systemic 16,16 DM PGE2 is cytoprotective in bile acid treated gastric mucosa. Such cytoprotection is dose dependent, is not a function of mucosal blood flow, and is unrelated to bicarbonate secretion. Rather the data suggest that maintenance of normal mucosal transport is responsible. (2) De-conjugated bile acids induce significantly greater physiologic damage to proximal gastric mucosa then do conjugated bile acid, a circumstance which may be related to the greater capacity of de-conjugated bile acids to extract integral proteins from the lipid layer of cell membranes. (3) Surface epitheleal cells probably represent the site responsible for the restrictive permeability to cations characteristic of normal proximal gastric mucosa.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 31, 1981
- Accession Number
- ADA203883
Entities
People
- Wallace P. Ritchie Jr.
Organizations
- University of Virginia