Targeted Peptide Specificity
Abstract
The goal of this project is to investigate specificity and high affinity of small peptide ligands to their receptor targets. A specific goal is to determine the conformation of small natural peptide ligands. In the last year two peptides were investigated by 2D-NMR, alpha-conotoxin SI, which targets to the nicotinic acetylcholine receptor (but discriminates between the Torpedo and mammalian receptors), and the 'sleeper' peptide, which contains 5 residues of gamma-carboxyglutamate. In addition, significant progress was made towards understanding how small cysteine-rich peptide ligands might be specifically folded in Conus venom ducts. A second long range goal is to use molecular genetics to develop synthetic ligands for predetermined targets. Keywords: Cone snails; Conus textile. (AW)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 31, 1989
- Accession Number
- ADA203973
Entities
People
- Baldomero Olivera
Organizations
- University of Utah