Central Catecholaminergic Regulation of ACTH and Vasopressin

Abstract

The putative neurotransmitters, L-glutamate and norepinephrine were microinjected (50nl) unilaterally into the paraventricular nucleus of pentobarbital-anesthetized rats. L-glutamate (0.5M) elicited a rise in plasma ACTH, vasopressin, and oxytocin and a profound drop in heart rate that was accompanied by no significant change in blood pressure. The bradycardia was blocked by pretreatment with pentolinium (ganglionic blocker) and attenuated by pretreatment with atropine. Microinjedtion of norepinephrine (.0001 M) also elevated plasma ACTH but had no effect on heart rate or blood pressure. Microinjection of phenylephrine at .0001 M also led to a rise in plasma ACTH, however microinjection of clonidine did not.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1988
Accession Number
ADA204418

Entities

People

  • Daniel N. Darlington
  • Mary F. Dallman

Organizations

  • University of California, San Francisco

Tags

DTIC Thesaurus Topics

  • Arteries
  • Autonomic Nervous System
  • Availability
  • Blood
  • Brain
  • California
  • Cardiovascular Physiological Phenomena
  • Catecholamines
  • Classification
  • Contracts
  • Heart Rate
  • Identification
  • Nervous System
  • Norepinephrine
  • Pituitary And Hypothalamic Hormones And Analogues
  • Security
  • Universities

Fields of Study

  • Biology
  • Chemistry
  • Medicine

Readers

  • Cardiovascular Physiology
  • Neuroscience