Role of Protein Phosphorylation in the Regulation of Neuronal Sensitivity

Abstract

The main project carried out in our laboratory has been focused on the finding that neural cells possess an ecto-protein kinase activity, which phosphorylates proteins localized at the outer surface of the plasma membrane. The main new findings reported here are that primary CNS neurons, cultured from the neostriatum of embryonic mouse brain, have an ecto-protein kinase and surface phosphoprotein substrates for its activity. These cells were found to store ATP within synaptic vesicles and secrete it in a calcium-dependent manner upon stimulation. These results open for investigation the role of extracellular protein phosphorylation in the regulation and adaptation of CNS neurons. Keywords: Reprints; Biochemistry; Neurotransmission; Monoclonal antibodies.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 30, 1988
Accession Number
ADA204610

Entities

People

  • Yigal H. Ehrlich

Organizations

  • University of Vermont

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Abstracts
  • Air Force
  • Blood Coagulation Factors
  • Brain
  • Cell Line
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Central Nervous System
  • Chemistry
  • Classification
  • Nervous System
  • Nucleotides
  • Proteins
  • Synapses
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular and Cellular Biochemistry
  • Neuroscience