Mycotoxicosis Caused by Aerosolized T-2 Toxin Administered to Female Mice

Abstract

Thymus, spleen, adrenal glands, and small intestine of female mice exposed to aerosolized T-2 mycotoxin were examined at postexposure hours (PEH) 0.25, 1,2,4,6,9,12, and 24. Lymphocyte necrosis was observed at PEH 1 in the thymus, spleen, and lamina propria and Peyer patches of the small intestine. Necrosis of small intestinal crypt epithelial cells was observed at PEH 2, and necrosis of parenchymal cells and increased number of neutrophils were seen in sinusoids of the adrenal cortex at PEH 4. These results indicated that the earliest microscopic evidence of T-2 mycotoxicosis after aerosol exposure was necrosis of lymphocytes in the thymus, spleen, and lamina propria and Peyer patches of the small intestine. Keywords: Phytotoxins, Toxic disease, Reprints.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1988
Accession Number
ADA204673

Entities

People

  • D. A. Creasia
  • J. D. Thurman
  • R. W. Trotter

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Adrenal Glands
  • Birds
  • Cells
  • Endocrine Glands
  • Epithelial Cells
  • Fungi
  • Glands
  • Intestines
  • Lymphatic System
  • Lymphocytes
  • Mass Spectrometry
  • Mucous Membrane
  • Rodents
  • Small Intestine
  • Tissues

Readers

  • Mycotoxin ecology in Amazonian ecosystems.
  • Toxicology/Environmental Toxicology