Autologous Bone Marrow Transplantation for Poor-Prognosis Neuroblastoma

Abstract

Neuroblastoma, a neoplasm of the sympathetic nervous system, is the most common extracranial tumor of childhood. Approximately 60% of all patients have only a 10% probability of long-term, disease-free survival if given conventional therapy that includes chemotherapy, local irradiation, and surgery. Recent pilot studies of intensive chemotherapy and total body irradiation (TBI) followed by allogeneic bone marrow transplantation (BMT) or autologous bone marrow transplantation (ABMT) have produced encouraging results. In this report, we update our original study in which 20 patients with advanced neuroblastoma underwent intensive four-drug chemotherapy, TBI, and ABMT or allogeneic BMT; in addition, we provide data from our current study regarding the clinical use of sedimentation, filtration, and magnetic immunobeads for the ex vivo removal of neuroblastoma cells from autologous marrow. Reprints.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1987
Accession Number
ADA204700

Entities

People

  • C. P. Reynolds
  • Carl Lenarsky
  • John Wells
  • Michael Selch
  • Robert C. Seeger
  • Stephen A. Feig
  • Thomas J. Moss

Organizations

  • Naval Medical Research Center

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Biomedical Research
  • Blood
  • Bone Marrow
  • Bones
  • Cells
  • Chemotherapy
  • Child Abuse
  • Diseases And Disorders
  • Drug Therapy
  • Feeding Methods
  • Health Services
  • Hospitals
  • Neoplasms
  • Neuroblastoma
  • Public Health
  • Therapy

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Immunology and Pathology
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech