Virulence Markers of Dengue Viruses
Abstract
Illnesses in humans caused by the four serotypes of dengue virus include pyrexia of unknown origin (POU), classical dengue fever (DF), dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). The expression of these disease outcomes follows a discernable pattern in regions of the world where dengue viruses are endemic. Variations with virulence of dengue viruses, as defined by their ability to cause severe illness, is proposed to be one of the factors that contribute severe illness, is proposed to be one of the factors that contribute to the DHF and DSS disease outcomes. the manifestation of these severe outcomes is also related to host factors. For effective prevention and control of dengue diseases, it is important to identify virulent strains of dengue viruses and to elucidate mechanisms which result in strains of dengue viruses and to elucidate mechanisms which result in multiple disease forms and patterns. The overall object of this research project is to establish whether monocyte-infectivity of the virus can be used as a marker for dengue virulence. Subsequently, other biological markers which are unique to virulent viral strains and that can be mapped on viral glycoprotein by monoclonal antibodies, will be determined in order to establish the role, if any, of the viral glycoprotein in conferring virulence to the virus. Knowledge of how the viral glycoprotein is involved in the expression of virulence may contribute toward the development of an effective recombinant vaccine.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 10, 1988
- Accession Number
- ADA204833
Entities
People
- James L. Hardy
- Srisakul C. Kliks
Organizations
- University of California, Berkeley