Local Irritation Toxicity Study of Hypertonic Saline/Dextran 70 (Trade Name) and Constituents in New Zealand White Rabbits
Abstract
The potential for local irritation following intravenous, paravenous, intra-arterial, intramuscular, and subcutaneous injections of hypertonic saline/ DEXTRAN 70 was evaluated with solutions of its major constituents, hypertonic saline (7.5%) and DEXTRAN 70 (6%) in normal saline, in male New Zealand White rabbits. Ringer's lactate was also evaluated as a control. Animals were observed for signs of local irritation at 4, 24, 48, and 72 hours after the injections. Intravenous injections (0.5 ml) of hypertonic saline or DEXTRAN 70 resulted in an increased incidence of bruises at the injection site relative to injections of hypertonic saline/DEXTRAN 70 and Ringer's lactate. Paravenous injection (0. 1ml) resulted in the transient formation of injections blebs by all 4 dosing solutions and isolated bruising at the hypertonic saline, hypertonic saline/ DEXTRAN 70, and DEXTRAN 70 sites. A high incidence of hematoma and bruise formation was observed at the intra-arterial sites (0.2 ml), but these changes were distributed equally among the four dosing solutions. These results suggest that hypertonic saline/Dextran and its constituents are no more irritating than ringer's lactate when administered by intravenous, paravenous, intraarterial, intramuscular, or subcutaneous injection.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1988
- Accession Number
- ADA204835
Entities
People
- Denzil F. Frost
- Don W. Korte Jr.
- G. D. Young
- Gary M. Zaucha
Organizations
- Letterman Army Hospital