Heat Exhaustion in a Rat Model: Lithium as a Biochemical Probe.
Abstract
Experimental methods have been developed and validated which will permit us to: 1) measure leakage of tissue enzymes (ALT, CPK, Alkaline phosphatase, LDH) during heat exposure in rats; 2) measure lithium concentrations in plasma using atomic absorption spectrophotometry; 3) measure total body water, extracellular fluid space, and intravascular fluid space in rats; 4) passively heat restrained rats and record changes in rectal temperature. Our objectives for future work include: 1) learn methods for study of unrestrained rats which are passively heated; 2) learn methods for study of rats actively heated using treadmill; 3) treat rats with lithium and determine whether passive restrained, unrestricted restrained, or actively heated lithium-treated rats can be differentiated from controls in terms of heating rate, tissue enzyme leakage, or body water distribution. Keywords: Fatigue physiology, Heat stroke, Heat exhaustion, Heat stress physiology. (aw)
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 08, 1988
- Accession Number
- ADA204894
Entities
People
- Steven H. Zeisel
Organizations
- Boston University