Pressure Suppresses Serotonin Release by Guinea Pig Striatal Synaptosomes

Abstract

Exposure to high pressure produces neurologic changes in humans which manifest as tremor, EEG changes, and convulsions. Since previous studies have implicated the involvement of the serotoninergic system in these symptoms, it was of interest to study serotonin release at high pressure. Synaptosomes isolated from guinea pig striatum were used to follow serotonin efflux at 68 ATA. The major observation was a decrease in Tritium serotonin release from depolarized striatal synaptosomes at 68 ATA. In view of the role of serotonin as an inhibitory neurotransmitter in this area, the observed decrease in synaptic release leads us to conclude that decreased serotoninergic activity in striatal neurons probably is contributing to the hyperexcitability associated with HPNS. Keywords: Hyperbaric conditions, Stress physiology, Reprints.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1988
Accession Number
ADA204970

Entities

People

  • A. J. Dutka
  • J. S. Colton
  • S. C. Gilman
  • S. C. Hsu

Organizations

  • Naval Medical Research Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Amino Acids
  • Biomedical Research
  • Brain
  • Cell Membrane
  • Cells
  • Cellular Structures
  • Central Nervous System
  • Cerebral Cortex
  • High Pressure
  • Membrane Potentials
  • Nerves
  • Nervous System
  • Neurotransmitters
  • Physiology
  • Rodents
  • Synapses

Fields of Study

  • Biology
  • Psychology

Readers

  • Neuroscience