Acute Dermal Toxicity of Diethyleneglycol Dinitrate (TEGDN) in Rabbits
Abstract
The acute dermal toxicity of triethyleneglycol dinitrate, TEGDN, was evaluated in five male and five female New Zealand White rabbits. Neat TEGDN (2 ml/kg) was applied topically to the clipped dorsal skin surface under a semi- occlusive wrap for 24 hours. No evidence was obtained of percutaneous absorption of quantities sufficient to produce systemic toxicity or death. Dermal signs could not be evaluated in two animals that began to molt during the study. Seven of the remaining eight rabbits exhibited very slight to slight erythema 1/2-hour after wrap removal and all but one had cleared by 72 hours. In this animal erythema persisted for 7 days after wrap removal. These data indicate that TEGDN does not produce systemic toxicity when administered by 24-hour topical application at a limit dose of 2 ml/kg. These data do suggest, however, that TEGDN has the potential to produce dermal irritation. Acute dermal toxicity, Triethyleneglycol dinitrate, TEGDN, Rabbit, Propellant, Munition.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1989
- Accession Number
- ADA205020
Entities
People
- Don W. Korte Jr.
- Earl W. Morgan
Organizations
- Letterman Army Hospital