A Comparative Study Regarding the Association of Alpha-2U Globulin with the Nephrotoxic Mechanism of Certain Petroleum-Based Air Force Fuels

Abstract

Fischer 344 male rats have a dose and time-dependent renal proximal tubular degeneration induced by certain hydrocarbon compounds. This degeneration my be associated with a low molecular weight urinary protein called alpha-2U globulin. We are using rat-strain variation of the alpha-2U globulin molecule and metabolic alteration of the urinary pH as methods to investigate the hydrocarbon-induced nephrotoxic response. Two significant advances have been made in the first year of this project: (1) We have developed a histochemical procedure to specifically evaluate changes in the renal epithelial lysosome, and (2) We have detected a rat strain difference in susceptibility to hydrocarbon-induced nephrotoxicity. Keywords: Toxins; Toxicity; Response biology.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1988
Accession Number
ADA205143

Entities

People

  • Thomas E. Eurell

Organizations

  • University of Illinois Urbana–Champaign

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Air Force
  • Anatomy
  • Animals
  • Biological Sciences
  • Cells
  • Cells (Biology)
  • Epithelial Cells
  • Fuels
  • Globulins
  • Hydrocarbons
  • Laboratory Animals
  • Lysosomes
  • Molecular Weight
  • Molecules
  • Organelles
  • Proteins

Readers

  • Molecular and Cellular Biology
  • Toxicology/Environmental Toxicology