Diagnosis and Management of Trichothecene in the Swine Model
Abstract
The efficacy of a variety of approaches for the treatment of iv induced acute T-2 toxicosis was assessed in rats and swine. (1) Oral (po) (superactivated charcoal (SAC), intravenous (iv), dexamethasone (DEX), intraperitoneal (ip), methylpredenisolone (MPSS), but not ip ascorbic acid, were effective post-toxin therapeutic agents in rats as measured by increases in survival times (ST). (2) Pre- and post-toxin (iv) treatment of rats with po SAC resulted in increased ST and decreased lesion severity in the duodenum, jejunum, and ileum. (3) SAC or Ambersorb resin XE-348F was effective in absorbing T-2 toxin vitro, and in prolonging the STs of rats given lethal (8 mg/kg) po doses of the toxin followed by po SAC or resin at 1 g/kg or less. SAC was a more effective binding agent than the resin. (4) Similarities in pharmacokinetic data for DEX in rats indicated that they may be an acceptable model for humans. Keywords: T-2 Toxin, Therapy, Cutaneous therapy, Combination therapy, Drug therapy, Metabolism, Gl Blood flow, Superactivated charcoal, Pathophysiology, Histopathology, Ascorbic acid, Dexamethasone, Dexamethasone pharmackinetics, Methylprednisolone, Ambersorb resin, Diactoxyscirpenol, Dexoynivalenol, Biotransformation, De-epoxidation, Analysis, Hydrolysis, Hydroxylation, Conjugation, Mass spectra, Metabolism.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1988
- Accession Number
- ADA205208
Entities
People
- Richard J. Lambert
- Steven P. Swanson
- Val R. Beasley
- Wanda M. Haschek-hock
- William B. Buck
Organizations
- University of Illinois Urbana–Champaign