Neuropeptide Modulation of Murine Erythropoiesis

Abstract

Neuropeptides, particularly the endogenous opioid peptides, function in the central nervous system (CNS) as potent analgesics in response to pain stimuli. One group of the endogenous opioid peptides, termed endorphins, is derived from beta-lipotropin, which, along with adrenocorticotropic hormone (ACTH), is a product of proopiomelanocorticotropin. In addition, the enkephalins, synthesized in both the brain and the intestinal tract, are molecules with structural homology to the N-terminal pentapeptide of the endorphins. Neuropeptide modulation of hematopoietic stem cell differentiation was studied in an in vitro murine system. Endorphins were able to influence the erythropoietin-dependent differentiation of bone marrow cells into erythroid colony forming units in a dose dependent manner. The effect on progenitor cell maturation were influenced by the conditions and time of exposure to the endorphins. The modulation of erythropoiesis by the endorphins suggests that these peptides may function as modifiers of the maturation of bone marrow cells. Reprints.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1987
Accession Number
ADA205225

Entities

People

  • Aftab A. Ansari
  • Jehane Fata
  • Lyle Sensenbrenner
  • Regina R. Skelly
  • Saul J. Sharkis

Organizations

  • Naval Medical Research Unit Three

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Bone Marrow
  • Bone Marrow Cells
  • Bones
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Classification
  • Endorphins
  • Hormones
  • Maturation
  • Modulation
  • Molecules
  • Peptide Growth Factors
  • Peptides
  • Pituitary And Hypothalamic Hormones And Analogues
  • Stem Cells

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology
  • Immunology and Pathology
  • Molecular and Cellular Biochemistry

Technology Areas

  • Biotechnology