Toxicokinetics: An Analytical Tool for Assessing Chemical Hazards to Man

Abstract

The Toxic Hazards Division has pioneered the development of toxicokinetic analysis for the study of the toxicity of various chemicals of importance to the U.S. Air Force. Toxicokinetic analysis permits calculation of tissue exposure based on biochemical, physiological, and physical chemical properties of the animal-chemical system. This paper describes the application of toxicokinetic analysis in the study and control of chemical hazards. Physiological models for both carbon tetrachloride and methylene chloride are discussed in relation to their ability to predict human kinetics and their use in estimating the risk of these chemicals to exposed humans. The emerging use of the toxicokinetic approach to analyze the mechanistic basis of chemical carcinogenesis is also discussed. Keywords: Fuels; Solvents; Hazardous materials; Exposure physiology; Protective clothing; Toxic tolerances; Toxicokinetics; Pharmacokinetics; Risk assessment; Physiological models; Reprints.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1988
Accession Number
ADA205523

Entities

People

  • Bruce O. Stuart
  • Harvey J. Clewell Iii
  • Melvin E. Andersen
  • Michael G. Macnaughton

Organizations

  • Armstrong Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Carbon Monoxide
  • Carbon Tetrachloride
  • Chemistry
  • Chlorides
  • Classification
  • Computer Programming
  • Dielectric Gases
  • Health
  • Kinetics
  • Materials
  • Metabolism
  • Methylenes
  • Risk
  • Risk Analysis
  • Toxic Hazards
  • Toxicity

Fields of Study

  • Environmental science

Readers

  • Environmental Engineering.
  • Systems Analysis and Design
  • Toxicology/Environmental Toxicology