Energy Failure of Vital Organs in Hypovolemia and Sepsis: Prevention by PGBx

Abstract

The objective was to determine the efficacy of a prostaglandin B1 oligomer 16,16-dimethyl-15-dehydro-PGB1, (PGB1)3 in preventing cellular acute injury and energy failure after tissue ischemia or chronic sepsis. An additional goal was to characterize the mechanisms of the drug's protective effects, whenever possible. On the basis of our data we conclude that (PGB1)3 can be effective in preventing cellular re-perfusion injury, as quantitated by measurements of mitochondrial function, but only under some narrowly defined conditions. It appears that these conditions are so limited that solid experimental proof of the drug's efficacy is difficult to generate. Keywords: Kidneys, Mitochondrial respiration, Adenine nucleotides, Pyruvate dehydrogenase, Hypovolemia.

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Document Details

Document Type
Technical Report
Publication Date
Nov 30, 1988
Accession Number
ADA205600

Entities

People

  • Leena Mela-riker

Organizations

  • Oregon Health & Science University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Absorption Spectra
  • Alcohols
  • Animals
  • Arteries
  • Chemistry
  • Cytochromes
  • Data Acquisition
  • Free Radicals
  • Ischemia
  • Mannitol
  • Mitochondria
  • Mitochondrial Proteins
  • Nucleotides
  • Oxygen Electrodes
  • Proteins
  • Pyruvates
  • Recovery

Readers

  • Cardiovascular Physiology
  • Molecular and Cellular Biochemistry
  • Systems Analysis and Design