Chemical Blistering: Cellular and Macromolecular Components

Abstract

The objective of this project is to establish the molecular and cellular lesions responsible for tissue destruction as a result of exposure to toxic environmental chemical, bis-(beta-chloroethyl) sulfide (BCES), are being studied in proliferating and differentiating cultures of epidermal keratinocytes obtained from neonatal rats and from newborn foreskin. Mustard, Keratinocyte tissue culture, Alkylation, Toxicity, Chemical blistering, mitochondria, Metabolism, DNA repair, Epidermal proliferation, Epidermal differentiation.

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Document Details

Document Type
Technical Report
Publication Date
Nov 15, 1984
Accession Number
ADA205748

Entities

People

  • Abhishek N. Kulkarni
  • I. A. Bernstein
  • M. J. Brabec
  • R. C. Conolly
  • R. H. Gray

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Alkylating Agents
  • Azo Compounds
  • Cell Membrane
  • Cells
  • Cellular Structures
  • Chemistry
  • Chlorides
  • Culture Techniques
  • Epidermis
  • Fish
  • Health Services
  • Intracellular Membranes
  • Laboratory Animals
  • Materials
  • Subcellular Fractions

Readers

  • Geochemistry
  • Molecular Biology and Genetics
  • Molecular and Cellular Biology

Technology Areas

  • Biotechnology