Attenuation of a Radiation-Induced Conditioned Taste Aversion after the Development of Ethanol Tolerance

Abstract

An attempt to reduce a radiation-induced conditioned taste aversion (CTA) was undertaken by rendering animals tolerant to ethanol. Ethanol tolerance, developed over 5 days, was sufficient to block a radiation-induced taste aversion, as well as an ethanol-induced CTA. Several intermittent doses of ethanol, which did not induce tolerance but removed the novelty of the conditioning stimulus, blocked an ethanol induced CTA but not the radiation- induced CTA. A CTA induced by doses of radiation up to 500 rads was attenuated. These data suggest that radioprotection developing in association with ethanol tolerance is a result of a physiological response to the chronic presence of ethanol not to the ethanol itself. Reprints.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 1988
Accession Number
ADA205805

Entities

People

  • Bernard M. Rabin
  • Walter A. Hunt

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Acquisition
  • Amines
  • Analysis Of Variance
  • Animals
  • Blood-Brain Barrier
  • Brain
  • Brain Stem
  • Chlorides
  • Computer Science
  • Fluids
  • Gamma Rays
  • Ionizing Radiation
  • Laboratory Animals
  • Maryland
  • Pseudomonas Infections
  • Radiation
  • Statistical Analysis

Fields of Study

  • Medicine

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Nuclear and Radiation Engineering.