Radiation-Induced Impairment of Neuronal Excitability

Abstract

Radiation causes a decrease in the synaptically evoked activity of CA1 hippocampal pyramidal cells. This effect is dose and dose-rate dependent. Hydrogen peroxide, which produces hydroxyl free radicals when combined with FE + 2, produces similar damage. In contrast, the radioprotectant, dithiothreitol, increases the excitability of hippocampal neurons. These studies indicate that radiation can directly affect the function of central neurons. Keywords: X rays, Radiation effects, Nerve transmission, Reprints, Stimulation physiology.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1988
Accession Number
ADA205812

Entities

People

  • J. M. Tolliver
  • K. L. Neel
  • T. C. Pellmar

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

DTIC Thesaurus Topics

  • Blood
  • Blood Flow
  • Blood-Brain Barrier
  • Brain
  • Cardiovascular Physiological Phenomena
  • Cells
  • Central Nervous System
  • Dose Rate
  • Electrophysiological Phenomena
  • Free Radicals
  • Frequency
  • Hippocampus
  • Ionizing Radiation
  • Nervous System
  • Radiation
  • Rocket Oxidizers
  • Rodents

Fields of Study

  • Biology
  • Physics

Readers

  • Electrochemical Engineering/ Fuel Cell Technologies
  • Neuroscience
  • Nuclear and Radiation Engineering.