Novel Tests for Rapid Detection of Insecticide Resistance in Mosquito Vectors

Abstract

During the third year of this contract, research emphasis was placed on the improvement and field evaluation of a practical test kit for the detection and monitoring of highly active esterases that are responsible for organophosphate insecticide resistance in mosquitoes. The evaluation of the test kit was performed on 40 field populations of mosquitoes in eight abatement districts in California and one in New Mexico. The results demonstrated the usefulness of the test kit in detecting Culex mosquitoes that are resistant to organophosphates due to the presence of highly active esterases. Other research has provided information on the geographical distribution of various highly active esterases in the U.S. and certain foreign countries, and on the classical and molecular genetics of these esterases. Keywords: Resistance biology; Insecticides; Mosquitoes; Resistance mechanisms; Esterases; Acetylcholinesterase; Gene amplification; Resistance detection; Test methods.

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Document Details

Document Type
Technical Report
Publication Date
Jan 25, 1989
Accession Number
ADA206316

Entities

People

  • George P. Georghiou

Organizations

  • University of California, Riverside

Tags

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • California
  • Central America
  • Contracts
  • Dermatologic Agents
  • Field Tests
  • Filter Paper
  • Genes
  • Genetics
  • Geographic Distribution
  • Molecular Genetics
  • New Jersey
  • New Mexico
  • North America
  • Organophosphates
  • Test And Evaluation
  • Test Methods

Readers

  • Neurotoxicology
  • Structural Health Monitoring of Composite Structures.
  • Vector-Borne Disease and Entomology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech