Primary Dermal Irritation Potential of Triethyleneglycol Dinitrate (TEGDN) in Rabbits

Abstract

The primary dermal irritation potential of triethyleneglycol dinitrate (TEGDN) was determined in male and female New Zealand White rabbits by using a modified Draize method. Very slight erythema was observed in 8 of 8 rabbits and very slight in edema in 5 rabbits by 1/2 to 1 hour after dosing. All rabbits had returned to normal by 72 hours after dosing. No other recognizable skin reaction was detected at any time during the 14-day observation period. The test compound was a mild irritant under conditions of this study. Keywords: Nitroglycerin; Propellants; Primary dermal irritation; Triethyleneglycol dinitrate; TEGDN; Rabbits; Mammalian toxicology; Munitions.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1989
Accession Number
ADA206344

Entities

People

  • Don W.
  • Larry D. Brown

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Alcohols
  • Biomedical Research
  • Ear Diseases
  • Health
  • Health Services
  • Irritants
  • Materials
  • Medical Personnel
  • New Zealand
  • Observation
  • Preventive Medicine
  • Rodents
  • Skin Diseases
  • Toxicity
  • Toxicology
  • Triple Base Propellants

Readers

  • Toxicology/Environmental Toxicology