Molecular Cloning of Human Gene(s) Directing the Synthesis of Nervous System Cholinesterases
Abstract
Cholinesterases (ChEs) are highly polymorphic serine hydrolases involved in the termination of neurotransmission in cholinergic synapses and neuromuscular junctions. Both the levels and the molecular forms of ChEs were shown to be modulated during development, denervation and regeneration processes in various species. In order to examine the molecular mechanisms underlying these phenomena in humans, we have used oligodeoxynucleotide probes to isolate full-length cDNA clones coding for human ChE. These clones are currently employed in our laboratory to study the biogenesis of human ChE at various levels of gene expression. Keywords: Cholinesterase; Chromosomal mapping; cDNA hybridization; Genomic clones; Xenopus oocytes microinjection.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1987
- Accession Number
- ADA206405
Entities
People
- Soreq Hermona
Organizations
- Weizmann Institute of Science