Alterations in Hepatic and Aortic Phospholipase-C Coupled Receptors and Signal Transduction in Rat Intraperitoneal Sepsis
Abstract
Sepsis, septic shock adn endotoxemia are characterized by a number of metabolic and cardiovascular alterations. In this paper we report that hepatic and aortic phospholipase-C coupled receptors are decreased in number during rat intraperitoneal sepsis; no changes in agonist or antagonist affinity or receptor-G protein coupling were identified. We also discovered that the alphal-adrenergic receptor mediated signal transduction system in rat aorta was modified as well during intraperitoneal sepsis. Thus, each step of the adrenergic signal cascade (PI hydrolysis, Ca++ mobilization and protein phosphorylation) was diminished. These results suggest that signal transduction involving aortic alphal-adrenergic receptors is attenuated during intraperitoneal sepsis. Previous investigators showed that the ability of NE and angiotensin II (AII) to raise the mean arterial pressure (MAP) was decreased during intraperitoneal sepsis. Other investigators found that the ability of NE, AII and Vaso to increase MAP during endotoxemia in the rat was similarly altered. We as well discovered that phenylephrine's capacity to augment the MAP was blunted during intraperitoneal sepsis. All these results imply that fundamental adaptations occur during sepsis which affect the ability of processor agents to maintain the blood pressure. Keywords: Vasoconstriction. Reprints.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1989
- Accession Number
- ADA206408
Entities
People
- Bryan L. Roth
- Eva A. Suba
- Joe A. Carcillo
- Raye Z. Litten
Organizations
- Naval Medical Research Center