Development of Medical Adjunctive Treatment for Acute Penetrating Head Injury

Abstract

Patients have been divided into two separate groups: 1) those who are in deep coma (Glasgow Coma Score (GCS) 3-5, and 2) those in light coma or awake, GCS 6-15. Although patients with an initial GCS 3-5 have a very poor prognosis (98% fatality), there is still considerable controversy nationwide over their management, particularly with regard to early surgery. The P.I. has thus chosen a factorial design to address two questions simultaneously on the same group of GCS 3-5 patients: The value of early surgery in this group, and the value of PEG-SOD. GCS 6-15 patients will all undergo early surgery and then be entered in the PEG-SOD trail. All patients participating in the trial are expected to benefit from it, since they will all receive intensive standardized ICU care. Keywords: Neurosurgery; Cellular pathophysiology; Acute Penetration; Therapeutic modalities.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1988
Accession Number
ADA206450

Entities

People

  • Andres M. Salazar

Organizations

  • Uniformed Services University of the Health Sciences

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Availability
  • Biomedical Research
  • Classification
  • Clinical Trials
  • Craniocerebral Trauma
  • Data Transmission
  • Diseases And Disorders
  • Experimental Data
  • Factorial Design
  • Head Injuries
  • Health Services
  • Hospitals
  • Maryland
  • Neurology
  • Security
  • Universities

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Neurotrauma and Rehabilitation Medicine.
  • Theoretical Analysis.