HTLV-1 (Human T-Cell Leukemia Virus 1) Seroconversion Study
Abstract
A data collection research center has been established on Okinawa for the purpose of studying the risk of HTLV-I transmission to active duty personnel stationed there. Research activities include a period prevalence serosurvy for HTLV-I in 5,267 personnel. Thirty-one of this group were positive by ELISA with confirmatory tests and full laboratory epidemiologic analysis pending. In addition, active duty personnel are being accessioned on arrival to Okinawa for prospective follow-up with repeat serologies and questionnaires throughout their tours to determine rates of seroconversion. Greater than 700 participants are currently accessioned. Preliminary results from the seroprevalence survey suggest that transmission rates may be low, however, final conclusions must await completion of the analysis of the seroprevalence draw and prospective study of personnel during their tours. HTLV-I, the first human retrovirus isolated, has been identified as the etiologic agent for Adult T-Cell Leukemia/ Lymphoma (ATLL). In addition, HTLV-I has been linked etiologically to a subset of patients with tropical Spastic Paraparesis (TSP) - a slowly progressive myelopathy. Transmission of the virus occurs parenterally, sexually, and from mother to child (predominantly via breast feeding).
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 17, 1989
- Accession Number
- ADA206498
Entities
People
- Stephanie K. Brodine