A Program for the Study of Skeletal Muscle Catabolism Following Physical Trauma.
Abstract
These two studies examine the role of prostaglandins as mediators of the catabolic response. In the first study, we examined the effects of a cyclooxgenase inhibition on the catabolic response to operative stress. In a second study we examined the effect of PG2 infusion on skeletal muscle proteolysis. Following laparotomy and retroperitoneal dissection, dogs increase skeletal muscle proteolysis and excrete increased urinary nitrogen. Pretreatment with a cyclooxygenase inhibitor (Ibuprofen) diminished this response in six paired animals when examining whole animal data. Amino acid flux data is presently being processed. In additional studies, PGE2 was infused in one hind limb and the flux of amino acids monitored in both lower extremities. Leg blood flow increased markedly in the limb receiving the PGE2; substrate flux is presently being analyzed. Keywords: Post traumatic proteolysis. (AW)
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 15, 1988
- Accession Number
- ADA206506
Entities
People
- Douglas W. Wilmore
Organizations
- Brigham and Women's Hospital