Atropine, Diazepam, and Physostigmine: Thermoregulatory Effects in the Heat-Stressed Rat

Abstract

We have reported that administration of atropine (A) to unrestrained, sedentary, heat-stressed rats resulted in a dose-dependent increase in heating rate (rate of rise of core temperature, C/min). Additionally, we have demonstrated that the decrements in treadmill endurance and increments in heating rate of physostigmine (PH)-treated running rats can both be restored to control levels of pretreating the animals with A and diazepam (D). Our objective in the present work was to determine if the administration of D+PH to A-treated unrestrained, sedentary, heat-stressed rats could improve their thermal tolerance. The combination of A+D+PH not only restores PH-induced performance and thermoregulatory decrements of rats exercised in a moderate environment, but also reduces A-induced heat intolerance. Keywords: Anticholinergic; Anticholinesterase; Animal; Hyperthermia; Anticonvulsant; Heat stress physiology.

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Document Details

Document Type
Technical Report
Publication Date
Dec 06, 1988
Accession Number
ADA206517

Entities

People

  • Candace B. Matthew
  • Ralph P. Francesconi
  • Roger W. Hubbard

Organizations

  • United States Army Research Institute of Environmental Medicine

Tags

DTIC Thesaurus Topics

  • Animals
  • Anticonvulsants
  • Atropine
  • Blood
  • Body Weight
  • Cooling
  • Digestive System Processes
  • Environment
  • Enzyme Inhibitors
  • Heat Loss
  • Human Body
  • Induced Hyperthermia
  • Intervals
  • Laboratory Animals
  • Losses
  • Military Research
  • Secretion

Readers

  • Exercise and Sports Science.
  • Neurotoxicology
  • Thermal Physics or Thermal Science.