Influence of Stress-Induced Catecholamines on Macrophage Phagocytosis
Abstract
Beta-Adrenergic receptor concentration and adenylate cyclase activity change with macrophage activation. Resident (R) and thioglycollate (TG)- stimulated macrophages (M0) have comparable concentrations of beta-adrenergic receptors (2136 + or - 143 and 2110 + or - 327 sites/cell respectively), while Bacillus Calmette Guerin (BCG)-activated macrophages have 62% fewer beta- adrenergic receptors (808 + or - 190 sites/cell). The increase in adenylate cyclase activity in TG-macrophages as compared to resident-macrophages results in increased sensitivity to catecholamines. FcR-mediated phagocytosis is dependent on FcR concentration, internalization and intra-cellular digestion of receptor-bound material. Catecholamines increase the concentration of FcR which in turn increases the availability of immune complexes for phagocytosis by the cell. Catecholamines also decrease internalization and/or digestion of FcR-bound immune complexes. Thus, the net effect of catecholamines on total phagocytosis is the consequence of the balance of independent effects of catecholamines on FcR concentration and the efficiency of internalization and degradation of bound material.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1989
- Accession Number
- ADA206608
Entities
People
- Christine K. Abrass
- Itamar B. Abrass
Organizations
- University of Washington