Cercarial Penetration Studies: Steps Toward Chemoprophylaxis in Schistosomiasis
Abstract
The focus of this research centered on elucidating the biochemical mechanisms involved in cercarial (Schistosoma mansoni) skin penetration and the evaluation of eicosanoid inhibitors as possible prophylactic agents. Nineteen areas of research were pursued during these three years: 1) The effect of low linoleate concentration on cercarial penetration and transformation. 2) The role of pH in cercarial eicosanoid production. 3) The effect of ibuprofen and esculetin on cercarial penetration, transformation and eicosanoid production. 4) Validation of the labelling technique for tracking cercarial penetration. 5) The effect of esculetin on cercarial penetration and transformation in vivo. 6) The biochemical mechanisms involved in cercarial transformation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 15, 1988
- Accession Number
- ADA206641
Entities
People
- A. C. Fusco
- B. Salafsky
Organizations
- University of Illinois College of Medicine