Acute Oral Toxicity of Diethyleneglycol Dinitrate (DEGDN) in Rats
Abstract
The acute oral toxicity of the nitrate ester, diethyleneglycol dinitrate (DEGDN), was determined in male and female Sprague-Dawley rats by using the oral gavage single-dose method. The median lethal dose (MLD) was 990.4 + or - 30.0 mg/kg for male rats and 753.1 + or - 35.9 mg/kg for female rats. Clinical signs produced by DEGDN included twitching, tremors, hypertonia, squinting, lacrimation, depression of grasping and righting reflexes, jumping, increased startle reflex, ataxia, cyanosis, inactivity, and prostration. The extent of the neurotoxic component of this clinical signs profile suggests that DEGDN possesses additional pharmacological properties than those routinely associated with the nitrate esters. The duration of clinical signs was acute. Most animals were exhibiting signs by 2 hours after dosing and had either died or cleared by 72 hours after dosing. According to the classification scheme of Hodge and Sterner, these results place DEGDN in the slightly toxic class.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1989
- Accession Number
- ADA207233
Entities
People
- Conrad R. Wheeler
- Don W. Korte Jr.
- John R. Ryabik
- Larry D. Brown
Organizations
- Letterman Army Hospital